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速效缓释避孕栓的溶出度试验是采用恒温水浴振荡器作为溶出试验仪,用高效液相色谱法检测杀精子剂(N_p-9)溶出含量,体内试验则是人阴道内给药后,在不同的时间对该部位进行X线拍摄观察栓的形态变化。实验表明:本栓体外溶出度试验与在人阴道内变化具有一定相关性。
Dissolution test for immediate-release sustained-release suppository was performed using a constant-temperature water bath shaker as a dissolution tester. The content of the spermicide (N_p-9) was measured by high performance liquid chromatography. After in vivo test, X-ray of the site at different times to observe the morphological changes of the suppository. Experiments show that: the in vitro dissolution test in vitro with human vaginal changes have some relevance.