谷氨酸在继发性脑损伤中的作用及治疗策略

• 作 者: 彭龙锋 雷鹏
• 机 构: 兰州军区兰州总医院全军脑肿瘤诊治中心,兰州军区兰州总医院全军脑肿瘤诊治中心 甘肃兰州730050,甘肃兰州730050
• 出 处: 西北国防医学杂志
• 发表日期: 2007年02期
• 关键词: 继发性脑损伤 谷氨酸 治疗

颅脑创伤(Traum atic brain in jury,TB I)在平、战时都极为常见,其对脑组织造成的损伤分为原发性和继发性。目前认为继发性脑损害因素涉及:谷氨酸(G lutam ate,G lu)的兴奋性神经毒性、自由基生成和脂质过氧化、Ca2+超载、炎性因子刺激及细胞凋亡等;其中G lu的兴奋性神经毒性

Traumatic brain injury (TBI) is very common during both peacetime and wartime. The damage to brain tissue is primary and secondary. At present, it is thought that secondary brain damage factors include excitatory neurotoxicity of Glutamine (G lu), free radical generation and lipid peroxidation, Ca2 + overload, inflammatory factor stimulation and apoptosis; among them, Excitotoxicity of G lu