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[目的]研究六味地黄汤对雌性去势小鼠子宫形态学的影响。[方法]将50只3月龄小鼠饲养2周后,随机取40只摘除双侧卵巢,余10只行假手术。40只去势小鼠随机分为4组;去势空白组、六味地黄汤高、中、低剂量组、观察各组用药后子宫形态的变化。[结果]六味地黄汤能够显著增加去势小鼠子宫重量,使去势小鼠子宫内膜明显增厚,并能明显增加子宫内腺体数目及血管分布。[结论]六味地黄汤可能直接作用子宫,改善子宫内膜的状态,从而缓解子宫萎缩的作用。
[Objective] To investigate the effect of Liuwei Dihuang Decoction on uterus morphology in female castration mice. [Method] Fifty 3-month-old mice were housed for 2 weeks. 40 ovariectomized ovariectomies were randomly selected and the remaining 10 sham operated. 40 castrated mice were randomly divided into 4 groups; castrated blank group, Liuweidihuang Decoction high, medium and low dose groups, observe the changes of uterine morphology after treatment. [Result] Liuweidihuang decoction could significantly increase uterine weight of ovariectomized mice, significantly thicken the endometrium of ovariectomized mice, and significantly increase the number and distribution of uterine glands. [Conclusion] Liuwei Dihuang Decoction may directly affect the uterus and improve the state of endometrium, so as to relieve the effect of uterine atrophy.