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Background: Left atrial (LA) function is an important determinant of left venr icular(LV) filling. However, the effect of pulmonary hypertension(PH) on LA mech anical function in chronic obstructive lung disease(COLD) has not been studied, yet. Methods: 49 patients with COLD and 25 controls were included in this study. Patients were divided into two subgroups: patients without PH(group 1, n=21) an d with PH (group 2, n=28). LA volumes were determined at mitral valve opening(Vm ax), at onset of atrial systole(Vp) and at mitral valve closure(Vmin) according to biplane area length method. The following LA parameters were calculated: pas sive emptying volume (PEV=Vmax Vp), conduit volume [CV=LV stroke volume (Vmax Vmin)], passive emptying fraction(PEF=PEV/Vmax), active emptying volume(AEV=V p Vmin), active emptying fraction(AEF=AEV/Vp), total emptying volume(TEV=Vmax V min), percent contribution of PEV, CV and AEV to LV stroke volume. Results: Vmax (p< 0.01), PEV(p< 0.001) and TEV(p< 0.05) were lower in group 2 than in the con trols, and the differences between group 1 and control group were insignificant (p >0.05). Vp, Vmin, CV and AEV did not differ among three groups. Percent contr ibution to LV filling of the PEV was decreased in group 2 when compared to group 1 (p< 0.05) and the controls (p< 0.01). Percent contribution to LV filling of t he AEV was increased in group 2 when compared to the controls (p< 0.05). There were inverse correlations between pu lmonary artery pressure and the following parameters: LV stroke volume (r=-0.43 , p< 0.01), mitral E/A (r=-54, p< 0.001), Vmax (r=-0.35, p< 0.05), PEV (r=-40 , p< 0.01) and PEF (r=-0.43, p < 0.01). Conclusion: This study shows that the a lterations of LA mechanical functions in patients with COLD are closely correlat ed to PH levels. Furthermore, these results underline the importance of maintain ing a sinus rhythm in these patients.
However, the effect of pulmonary hypertension (PH) on LA mech anical function in chronic obstructive lung disease (COLD) has not been studied, yet . Patients: 49 patients with COLD and 25 controls were included in this study. Patients were divided into two subgroups: patients without PH (group 1, n = 21) an d with PH (group 2, n = 28). LA volumes were determined at mitral valve opening (Vm ax) at onset of atrial systole (Vp) and at mitral valve closure (Vmin) according to biplane area length method. The following LA parameters were calculated: pas sive emptying volume (PEV = Vmax Vp) , passive volume fraction (PEF = PEV / Vmax), active emptying volume (AEV = Vp Vmin), active emptying fraction (AEF = AEV / Vp), total emptying Results: Vmax (p <0.01), PEV (p <0.001) and TEV (p <0.05) were lower in group 2 than in the con trols, and the differences between group 1 and control group were insignificant (p> 0.05). Vp, Vmin, CV and AEV did not differ among three groups. Percent contr ibution to LV filling of the PEV was decreased in group 2 when compared to group 1 (p <0.05) and the controls (p <0.01). Percent contribution to LV filling of t AE AE was increased in group 2 when compared to the controls (p <0.05). There were inverse correlations between pu lmonary artery pressure and the following parameters: LV stroke volume (r = -0.43, p <0.01), mitral E / A P <0.05), PEV (r = -40, p <0.01) and PEF (r = -0.43, p <0.01). Conclusion: This study shows that a lterations of LA mechanical functions in patients with COLD are closely correlated to PH levels. Furthermore, these results underline the importance of maintain ing a sinus rhythm in these patients.