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最近有他汀随机临床试验分析报告显示,他汀治疗者糖尿病发病率较高。据对13项空白随机试验荟萃分析表明他汀治疗者显示9%(95%CI:12%~17%)糖尿病高风险比,另外的5个二级预防试验强化与次强化他汀治疗比较,报告强化者12%(4%~22%)较高的糖尿病风险,一种可能解释是这种偏差是由于存活时间不同,当处于糖尿病高风险患者在他汀治疗下存活期较长。为此本文对取自500位英国全科医师2000年1月至2010年12月,285860例50~84岁男女患者的电子病历进行了
A recent randomized clinical trial of statin reports showed that statin therapy was associated with a higher prevalence of diabetes. A meta-analysis of 13 randomized trials found that statin-treated patients showed a high risk of diabetes mellitus of 9% (95% CI: 12% to 17%) and an additional five secondary prevention trials of intensive versus statin treatment, One of 12% (4% -22%) of patients with a higher risk for diabetes mellitus, one possible explanation is that this deviation is due to different survival time, when patients with high risk of diabetes longer survival under statin therapy. To this end, this article from the United Kingdom from 500 British general practitioners from January 2000 to December 2010, 285860 male and female patients aged 50 to 84 were electronic medical records