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目的：观察抗疲劳１号（ＡＦ－１）对游泳运动大鼠血液ＡＴＰ和乳酸，以及脑和肌肉组织中ＡＴＰ含量的影响。方法：用生物发光法测定６组不同游泳强度大鼠血液和组织中ＡＴＰ含量；血乳酸含量变化用乳酸自动分析仪监测。结果：给药组大鼠游泳１０ｍｉｎ，血中ＡＴＰ含量明显高于对照组；血中乳酸含量明显低于对照组（Ｐ＜００１）。在游泳力竭鼠中，给药组血ＡＴＰ含量也较对照组高；而血乳酸含量较对照组低（Ｐ＜００５，Ｐ＜００１）。给药大鼠中，游泳１０ｍｉｎ组肌肉ＡＴＰ含量明显高于对照组（Ｐ＜００１）；游泳力竭组仍可保持在对照组水平（游泳时间不同）。给药鼠游泳１０ｍｉｎ和力竭两组脑组织中ＡＴＰ含量与未给药动物无明显差异，但未游泳组明显高于对照组。未游泳给药鼠肌肉中ＡＴＰ含量也明显高于对照组（Ｐ＜００５，Ｐ＜００１）。结论：抗疲劳１号具有抗疲劳功用，可能通过增加组织ＡＴＰ的生成和贮存，促进能量代谢，减少乳酸堆积，进而增加运动强度及运动时间
Objective: To observe the effect of anti-fatigue No.1 (AF-1) on ATP and lactic acid in blood and ATP content in brain and muscle tissues of swimming rats. Methods: The content of ATP in the blood and tissues of six groups of rats with different swimming strength was measured by the method of bioluminescence. The change of the content of lactate was monitored by automatic analyzer of lactic acid. Results: The swimming time of 10 min in the administration group was significantly higher than that in the control group. The content of lactic acid in blood was significantly lower than that of the control group (P <001). In swimming exhaustive rats, the content of blood ATP in the administration group was also higher than that in the control group, while the content of blood lactate was lower than that in the control group (P <005, P <001). In the administration rats, the muscle ATP content in the swimming 10 min group was significantly higher than that in the control group (P <001); the swimming exhaustion group could still maintain the level of the control group (the swimming time was different). Administration of swimming 10min and exhaustive brain tissue ATP content and no administration of animals no significant difference, but no swimming group was significantly higher than the control group. The ATP content in the muscles of non-swimming rats was also significantly higher than that in the control group (P <005, P <001). Conclusion: Anti-fatigue No.1 has the anti-fatigue effect, which may promote the metabolism of energy and reduce lactic acid accumulation by increasing the production and storage of ATP in tissues, thus increasing exercise intensity and exercise time