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动物实验和临床都有证据提示生殖激素影响癫痫发作.雌激素降低哺乳类动物电休克和化学性诱发癫痫的阈值,并能增加月经性癫痫妇女的痫样脑电图活动.而黄体酮则提高动物的癫痫阈值和减少妇女发作间期的痫样脑电图活动.在排卵的月经周期中,癫痫发作频率的变化与血清中雌二醇和黄体酮比率相关.在无排卵的月经周期中,由于黄体酮分泌低,癫痫发作频率增高.黄体酮疗法虽可减少癫痫发作次数,但对月经性癫痫或生殖内分泌紊乱的妇女并不是特有的.克罗米芬是雌激素类似体(clomiphene analogue),兼有抗雌激素及类雌激
Animal experiments and clinical evidence that reproductive hormones affect epileptic seizures.Estrogen decreases the threshold of electroshock and chemically induced epilepsy in mammals and increases the activity of epileptiform EEG in women with menopausal epilepsy, whereas progesterone increases Animal epilepsy threshold and epileptiform EEG activity reducing inter-seizure episodes During the menstrual cycle of ovulation, changes in the frequency of seizures correlate with the ratio of estradiol to progesterone in the serum In the anovulatory menstrual cycle, due to Low progesterone secretion and increased seizure frequency Progesterone therapy, although reducing the number of seizures, is not specific to women with menopausal or epileptic endocrine disorders Clomiphene is a clomiphene analogue that combines both Anti-estrogen and estrogen-like