【摘 要】
：
A novel and efficient method was developed for the synthesis of diarylpyrazole derivatives as cannabinoid CB1 receptor antagonist via four step reactions.The ke
【机 构】
：
Department of Biochemical Engineering,Zhejiang Hisun Pharmaceutical Co.
【基金项目】
：
教育部新世纪优秀人才支持计划;the Outstanding Youth Foundation of Heilongjiang Province,China
论文部分内容阅读
A novel and efficient method was developed for the synthesis of diarylpyrazole derivatives as cannabinoid CB1 receptor antagonist via four step reactions.The key step was the synthesis of a diarylpyrazole skeleton,which involved initial condensation of the sodium salt of compound 12 with diazonium compounds,and further cyclization by heating at reflux in acetic acid.Eight diarylpyrazole derivatives and nine new synthesized compounds were cha racterized by 1H NMR,IR,MS,and elemental analysis.The reaction conditions were mild and the overall yields of the target compounds ranged from 26% to 44%.
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