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采用紫外分光光度法测定了95例煤工尘肺患者27名煤矿接尘工人(X线表现为o~+)和33名健康对照者的血清血管紧张素Ⅰ转换酶(SACE)活性。结果表明,煤工尘肺患者和煤矿接尘工人的SACE活性均明显高于健康对照组(P<0.01),煤工尘肺患者与接尘工人之间则无明显差异。煤工尘肺患者的SACE活性及其+2SD的百分比显示有随期别增高而增加的趋势,但无显著意义(P<0.05)。在10年内有明显进展的尘肺患者中,SACE活性>+2SD的占53.8％。因而认为,煤工尘肺SACE活性升高应归因于病变的进展,而不是其严重程度。
The serum level of angiotensin Ⅰ converting enzyme (SACE) activity was measured by UV spectrophotometry in 27 workers exposed to dust in coal miners with pneumoconiosis (X ~ +) and 33 healthy controls. The results showed that the SACE activities of coal miners with pneumoconiosis and those exposed to coal mines were significantly higher than those of healthy controls (P <0.01). There was no significant difference between coal miners with pneumoconiosis and workers exposed to dust. SACE activity and its percentage of + 2SD in coal worker’s pneumoconiosis patients showed a trend of increasing with the rising trend, but no significant difference (P <0.05). Among pneumoconiosis patients with significant progression within 10 years, SACE activity> +2 SD accounted for 53.8%. Therefore, it is considered that the increase of SACE activity in coal workers’ pneumoconiosis should be attributed to the lesion’s progression rather than its severity.