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目的:使用聚肌胞联合炎琥宁治疗轮状病毒肠炎观察其疗效。方法:轮状病毒肠炎60例随机分为治疗组30例,对照组30例,两组年龄、性别、病程、病情程度上经统计学处理无显著性(P>0.05),具有可比性。治疗组运用聚肌胞肌注,1次/日,同时给予炎琥宁静脉滴注,1次/日,对照组给以病毒唑治疗,静脉滴注,1次/日。两组常规给以双歧杆菌三联活菌肠溶胶囊口服,并予补液,维持水电解质平衡,退热等对症支持治疗。结果:治疗组痊愈18例,有效11例,无效1例,总有效率96.6%;对照组痊愈14例,有效7例,无效9例,总有效率70%.两组总有效率比较,差异具有高度统计学意义(P<0.01)。结论:聚肌胞联合炎琥宁治疗轮状病毒肠炎疗效明显优于病毒唑,值得推荐临床使用。
OBJECTIVE: To investigate the therapeutic effect of polyinosine and mesylate on rotavirus enteritis. Methods: 60 cases of rotavirus enteritis were randomly divided into treatment group (n = 30) and control group (n = 30). There was no significant difference between the two groups in age, sex, course of disease and severity of illness (P> 0.05). The treatment group was given intramuscular injection of polymyosine once a day, meanwhile, Yanhu Ning was given intravenously once a day, while the control group was treated with ribavirin, intravenously once a day. Two groups of conventional to bifidobacterium triple live bacteria enteric-coated capsules oral and rehydration to maintain water and electrolyte balance, fever and other symptomatic and supportive treatment. Results: In the treatment group, 18 cases were cured, 11 cases were effective, 1 case was ineffective, and the total effective rate was 96.6%. In the control group, 14 cases were cured, 7 cases were effective, 9 cases were ineffective and the total effective rate was 70%. With a high degree of statistical significance (P <0.01). CONCLUSION: Polymyosin combined with metronidazole is superior to ribavirin in the treatment of rotavirus enteritis, which is recommended for clinical use.