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本文用超抗原葡萄球菌肠毒素B(SEB)诱导外周血淋巴细胞增殖。结果显示出微量超抗原能诱导外周血淋巴细胞的增殖,大量的增殖反应发生在SEB刺激后的第5天,增殖的细胞是CD4~+T细胞,它们由刺激前的27％增加到42％。外周血活化的T细胞不依赖外源性IL-2:大量内源性IL-2的存在抑制T细胞的增殖反应。伴随CD4~+T细胞的增殖,CD25和CD69分子表达明显增加。提示SEB能改变外周血T细胞表面的分子表达。
In this paper, superantigen staphylococcal enterotoxin B (SEB) induced peripheral blood lymphocyte proliferation. The results showed that the superantigen can induce the proliferation of peripheral blood lymphocytes, a large number of proliferative responses occurred on the 5th day after SEB stimulation, and the proliferating cells were CD4 ~ + T cells, which increased from 27% before stimulation to 42% . Peripheral blood-activated T cells are not dependent on exogenous IL-2: The presence of large amounts of endogenous IL-2 inhibits T cell proliferative responses. With the proliferation of CD4 ~ + T cells, CD25 and CD69 molecules were significantly increased. It is suggested that SEB can change the molecular expression of T cell surface in peripheral blood.