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尿道致病性大肠杆菌粘附于尿道上皮细胞是引起泌尿道感染的重要始动因素,抑制或阻止细菌的粘附可以预防和治疗泌尿道感染。泌尿道感染属中医下焦湿热病,用清利湿热的中药治疗,疗效显著,但尚缺乏现代医学科学技术对其机理的阐明。作者比较了清热利湿、淡渗利湿及辛温解表的三种不同中药方剂对尿道致病性大肠杆菌的抑菌、杀菌作用,凝集人p型红细胞以及粘附尿道上皮细胞的作用。实验结果表明,三种中药方剂均无明显的抑菌和杀菌作用。但清热利湿中药方剂能明显地抑制屎道致病性大肠杆菌、凝集人p型红细胞和粘附于人尿道上皮细胞;而辛温解表方剂对原道致病性大肠杆
Urethropathogenic Escherichia coli adheres to urethral epithelial cells and is an important initiating factor for urinary tract infection. Inhibiting or preventing bacterial adhesion can prevent and treat urinary tract infections. The urinary tract infection is a Chinese medicine under the coke damp-heat disease, with clear and damp heat of traditional Chinese medicine treatment, a significant effect, but the lack of modern medical science and technology to clarify its mechanism. The authors compared the antibacterial and bactericidal effects of three different Chinese herbal formulas, heat-clearing and damp-heating, light infiltration and dampness detoxification, and Xin Wenjie, on agglutinating human p-type red blood cells and adhering to urethral epithelial cells. The experimental results show that there are no obvious antibacterial and bactericidal effects of the three Chinese herbal formulas. However, the Qingre Lishi Chinese herbal formula can significantly inhibit the pathogenic E. coli, agglutinate human p-type red blood cells, and adhere to human urinary tract epithelial cells; and Xin Wen Jie Bu prescriptions to pathogenic large intestine stems