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目的 确定中国北方人群在腰椎和股骨部位峰值骨大小和体密度的性别差异 ,并分析影响其大小的因子。方法 年龄 15至 4 0岁 2 5 6例健康男性和 30 9例健康女性 ,他们的腰椎和股骨颈的骨大小和体积骨密度用双能X线骨密度仪测量。椎体和股骨颈近似为圆柱体 ,骨体积V =π× (宽度 2 ) 2 ×高度 ,vBMD =BMC 体积。结果 椎体峰值BMC ,体积和vBMD女性在 30～ 4 0岁达到峰值 ,而男性 15～ 17岁达到峰值。椎体和股骨颈的BMC男性比女性高 18 1%～ 2 6 7% ,而骨体积相应高 2 8 5 %～ 32 0 % ,这样vBMD男性比女性低 4 0 %～ 8 3% (P <0 0 1)。初潮较晚 (≥ 15岁 )绝经前妇女比来潮较早者 (≤ 12岁 ) ,BMC低 10 % (P <0 0 5 )。男性抽烟者与非抽烟者骨大小和vBMD没有统计学差异。饮酒也没有观察到明显的效应。结论 中国男性比女性有较低的vBMD ,这可能部分地解释中国男性有较高骨折发生率的原因
Objective To determine the gender differences in peak bone mass and body density of lumbar spine and femur in North China and to analyze the factors influencing their size. Methods A total of 256 healthy men and 309 healthy women aged 15 to 40 years old were enrolled in this study. Their lumbar and femoral neck bone mass and volumetric BMD were measured by dual-energy X-ray absorptiometry. The vertebral body and femoral neck were approximately cylindrical with a bone volume V = π × (width 2) 2 × height and vBMD = BMC volume. Results The vertebral peak BMC, volume and vBMD women peaked at 30 to 40 years old, while those at 15-17 years old peaked. BMC males in the vertebral body and femoral neck were 18.1% -267% higher than females and correspondingly 28.5% -320% in the bone mass, thus reducing the prevalence of vBMD by 40% -38% in females compared with females (P < 0 0 1). Postmenopausal women (≥ 15 years) had 10% lower BMC (P <0 05) than those with earlier cramps (≤ 12 years) and later menarche (≥ 15 years). There was no significant difference in bone size and vBMD between male smokers and non-smokers. No significant effect was observed with alcohol consumption. Conclusions Chinese males have lower vBMD than females, which may partly explain why males have a higher incidence of fractures in Chinese men