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[目的]观察右美托咪定连续静脉输注用于小儿CT 检查期间镇静效果。[方法]CT检查前不合作的儿童343例按年龄分为三组，即婴儿组（7 d至11个月，78例），幼儿组（1～3岁，137例），学龄前组（4～6岁，128例）。随机将三组患儿分别予水合氯醛灌肠、静注咪唑安定、静注右美托咪定或静注右美托咪定复合小剂量的咪唑安定静注四种方法镇静，并对镇静效果进行观察。[结果]婴儿组四种方法镇静效果无统计学差异（P ＞0．05）；幼儿组和学龄前组小儿静注咪唑安定、静注右美托咪定镇静效果无统计学差异（P ＞0．05），与注咪唑安定、静注射右美托咪定方法相比，静注右美托咪定复合小剂量的咪唑安定方法幼儿组和学龄前组儿童诱导睡眠时间和自然清醒时间缩短，镇静效果明显提高（ P ＜0．05）。[结论]水合氯醛灌肠、静注咪唑安定、静注右美托咪定、静注右美托咪定复合小剂量的咪唑安定方法均可用于婴儿组、幼儿组、学龄前组儿童镇静制动，但右美托咪定复合小剂量的咪唑安定方法，用于小儿CT 检查前镇静可取得更好的效果。“,”[Objective]To observe the sedation effect of dexmedetomidine continuous intravenous infusion in children during CT examination .[Methods]According to the age ,343 uncooperative children before CT ex-amination were divided into infant group(7 days-11 months ,n =78) ,toddler group (1~3 years ,n =137) , pre-school group (4~6 years ,n=128) .Pediatric patients in three groups were randomized to be given four methods of sedation such as chloral hydrate enema ,intravenous midazolam ,intravenous dexmedetomidine or dexmedetomidine combined with a small dose of midazolam .The sedative efficacy was observed .[Results]There was significant difference in the sedative efficacy among four sedation methods in infant age group ( P>0 .05) .There was no significant difference in the sedative efficacy between intravenous midazolam and dexme-detomidine in toddler group and pre-school group( P > 0 .05) .Compared with intravenous midazolam or dexmedetomidine ,intravenous dexmedetomidine combined with a small dose of midazolam in toddler group and preschool children group had shorter sleep time and natural awake time ,and the sedative efficacy obviously in-creased( P <0 .05) .[Conclusion] Chloral hydrate enema ,intravenous midazolam ,intravenous dexmedetomi-dine or intravenous dexmedetomidine combined with a small dose of midazolam can be used for sedation and clam in children of infant group ,toddler group and pre-school group .But dexmedetomidine combined with a small dose of midazolam for sedation in children before CT examination can obtain better efficacy .