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目的研究糖基化终产物(AGEs)与血管细胞黏附分子1(VCAM-1)间的关系,探讨AGEs在动脉粥样硬化中的作用。方法分别抽取30例健康人群(A组)、32例糖尿病患者(B组)及36例冠心病患者(C组)的外周血液,用ELISA法检测各组血清中AGEs与VCAM-1的水平。结果 B组AGEs和VCAM-1浓度均较A组明显升高[(12.43±0.52)U/ml vs. (8.82±0.36)U/ml和(735.50±55.75)pg/ml vs. (417.80±27.34)pg/ml](P<0.01);而C组AGEs和VCAM-1浓度为(9.04±0.38)U/ml和(417.80±27.34)pg/ml,均与A组相仿(P>0.05)。B组、C组血清中AGEs浓度与VCAM-1浓度均呈显著正相关(r=0.7347、0.6329,P<0.01)。结论 AGEs在体内可以促进VCAM-1的分泌,这可能是糖尿病患者易患动脉粥样硬化的重要机制之一。
Objective To investigate the relationship between advanced glycation end products (AGEs) and vascular cell adhesion molecule 1 (VCAM-1) and to explore the role of AGEs in atherosclerosis. Methods Peripheral blood of 30 healthy people (group A), 32 diabetic patients (group B) and 36 patients with coronary heart disease (group C) were collected. The serum levels of AGEs and VCAM-1 in each group were detected by ELISA. Results The concentrations of AGEs and VCAM-1 in group B were significantly higher than those in group A [(12.43 ± 0.52) U / ml vs. (8.82 ± 0.36) U / ml and (735.50 ± 55.75) pg / ml vs. (417.80 ± 27.34 (P <0.01). The concentrations of AGEs and VCAM-1 in group C were (9.04 ± 0.38) U / ml and (417.80 ± 27.34) pg / ml, respectively, which were similar to those in group A (P> 0.05). The concentrations of AGEs in serum of group B and group C were positively correlated with the concentration of VCAM-1 (r = 0.7347,0.6329, P <0.01). Conclusion AGEs can promote the secretion of VCAM-1 in vivo, which may be one of the most important mechanisms of diabetic patients susceptible to atherosclerosis.