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目的 :考察半乳糖凝集素3(galectin-3)与慢性心力衰竭分级、治疗和预后之间的相关性。方法 :选取泸州医学院附属医院2011年1月—2013年1月心血管内科就诊的患者140例,按心功能分级分为Ⅱ级组(47例)、Ⅲ级组(50例)、Ⅳ级组(43例),检测患者血galectin-3、超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)、N末端B型利钠肽原(N-terminal probrain natriuretic peptide,NT-pro BNP)、左室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)、左心室射血分数(ejection fraction,EF),比较治疗有效患者与无效患者galectin-3表达差异,分析galectin-3与预后之间的关系。结果:galectin-3与hs-CRP、NT-pro BNP、LVEDD呈正相关(r=0.912,P<0.05;r=0.772,P<0.05;r=0.564,P<0.05),与EF呈负相关(r=-0.612,P<0.05);治疗有效组galectin-3显著高于无效组(t=3.81,P<0.01);发生心脏事件组galectin-3显著高于未发生心脏事件组(t=3.04,P<0.01)。结论:galectin-3与慢性心力衰竭密切相关,可用于慢性心力衰竭的临床诊断。
Objective: To investigate the correlation between galectin-3 and grade, treatment and prognosis of chronic heart failure. Methods: One hundred and fourteen patients were enrolled in Department of Cardiology, Affiliated Hospital of Luzhou Medical College from January 2011 to January 2013. The patients were divided into two groups according to their cardiac function: grade Ⅱ (47 cases), grade Ⅲ (50 cases), grade Ⅳ (N = 43). The levels of galectin-3, hs-CRP, N-terminal probrain natriuretic peptide (NT-pro (BNP), left ventricular end-diastolic dimension (LVEDD), and left ventricular ejection fraction (EF). The difference between galectin-3 and prognosis The relationship between. Results: There was a positive correlation between galectin-3 and hs-CRP, NT-pro BNP and LVEDD (r = 0.912, P <0.05; r = 0.772, P < (t = 3.81, P <0.01); galectin-3 was significantly higher in patients with cardiac events than those without cardiac events (t = 3.04, r = -0.612, , P <0.01). Conclusion: galectin-3 is closely related to chronic heart failure and can be used in clinical diagnosis of chronic heart failure.