论文部分内容阅读
目的探讨新疆喀什地区维吾尔族人群高尿酸血症与冠心病及冠状动脉狭窄程度之间的相关性。方法 采用病例对照研究,选择2006年1月～2010年9月在我院心内科住院并行冠状动脉造影检查确诊的维吾尔族冠心病(CHD)患者525例;对照组582例,为同期入院行冠状动脉造影检查结果阴性或其他检查排除冠心病者。对所有纳入对象测定禁食12h后静脉血清尿酸值及其他生物化学指标,并结合冠脉造影情况,探讨高尿酸血症与冠心病及冠脉狭窄程度的关系。结果 CHD组高尿酸血症的患病率为9.33%,明显高于对照组的4.81%,并具有统计学意义(P<0.05);血尿酸水平(346.45±102.41)μmol/L显著高于对照组(312.18±101.26)μmol/L(P<0.05)。多因素Logistic回归分析显示,在校正了年龄、吸烟、高血压、糖尿病、血脂异常等传统危险因素作用后发现,高尿酸血症是冠心病的独立危险因素(OR=1.837,95%CI:1.181～3.415;P<0.05)。CHD组不同冠脉病变支数亚组之间高尿酸血症患病率及血尿酸水平比较未见明显统计学差异(P>0.05)。结论本研究人群高尿酸血症是冠心病发生的独立危险因素,但血尿酸水平与冠脉狭窄程度无明显相关性。
Objective To investigate the correlation between the hyperuricemia and coronary heart disease and the degree of coronary artery stenosis in Uygur population in Kashgar region of Xinjiang. Methods A case-control study was conducted in 525 Uighur CHD patients diagnosed in our hospital from January 2006 to September 2010 with coronary angiography. In the control group, 582 patients were hospitalized with coronary artery disease Angiography negative results or other tests to rule out coronary heart disease. The venous serum uric acid levels and other biochemical parameters were determined after 12-hour fasting in all the subjects. The relationship between hyperuricemia and coronary artery disease and coronary artery stenosis was analyzed. Results The prevalence of hyperuricemia in CHD group was 9.33%, which was significantly higher than that in control group (4.81%, P <0.05). The level of serum uric acid (346.45 ± 102.41) μmol / L was significantly higher than that in control group Group (312.18 ± 101.26) μmol / L (P <0.05). Multivariate Logistic regression analysis showed that hyperuricemia was an independent risk factor for coronary heart disease after adjusting for traditional risk factors such as age, smoking, hypertension, diabetes and dyslipidemia (OR = 1.837, 95% CI: 1.181 ~ 3.415; P <0.05). No significant difference was found in the prevalence of hyperuricemia and serum uric acid between different subgroups of coronary lesions in CHD group (P> 0.05). Conclusions Hyperuricemia is an independent risk factor for coronary heart disease in our study population. However, there is no significant correlation between serum uric acid level and coronary artery stenosis.