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环肽分子通过主链骨架中C=O和N—H形成分子间网络氢键,以β-片层反平行方式堆积可形成中空管状结构。通过控制环肽的结构和尺寸,或修饰具有不同功能的基团,可获得多种结构和性能的肽纳米管。本文综述了环肽分子自组装成纳米管的应用研究成果。首先介绍了带合适疏水性侧链的环肽纳米管在模拟生物跨膜离子通道方面的实验和理论研究进展,重点论及环肽纳米管的结构、极性和侧链的疏水性等对离子通道传输行为的影响以及分子动力学(MD)模拟研究水通道的进展。进而介绍了环肽纳米管用作生物传感器模板,与功能性(如电性、光学性和磁性)纳米材料合成制备生物传感器的实验研究成果,接着介绍了环肽纳米管作为药物或药物载体潜在的应用前景,特别是在某些抗菌和抗感染药物开发设计中的应用以及环肽在不同极性环境中自组装过程微观机制的MD模拟研究,最后介绍了环肽纳米管作为模板,制备磁性、电性纳米材料方面的实验和理论研究进展。
Cyclic peptide molecules through the main chain skeleton C = O and N-H to form intermolecular network hydrogen bonds, β-sheet anti-parallel accumulation of hollow tubular structure can be formed. By controlling the structure and size of the cyclic peptide or modifying groups having different functions, peptide nanotubes of various structures and properties can be obtained. This review summarizes the application of cyclic peptide self-assembly into nanotubes. First, the experimental and theoretical research progress of cyclic peptide nanotubes with appropriate hydrophobic side chains in the simulation of biological transmembrane ion channels is reviewed. The structure, polarity and side-chain hydrophobicity of cyclic peptide nanotubes Effects of channel transport behavior and molecular dynamics (MD) simulation on water channel progression. Furthermore, we introduce the experimental research results of cyclic peptide nanotubes used as biosensor templates to synthesize biosensors with functional (such as electrical, optical and magnetic) nanomaterials, and then introduce the potential of cyclic peptide nanotubes as drug or drug carriers Application prospects, especially in some antimicrobial and anti-infective drug development and design of the application of cyclic peptides in different polarities of the self-assembly process of the micro-mechanism of MD simulation, and finally introduced the cyclic peptide nanotubes as a template for the preparation of magnetic, Progress in Experimental and Theoretical Studies on Electrical Nanomaterials.