论文部分内容阅读
The title Pt-Guo compound was synthesized and isolated by the reaction between cis-[Pt(NH3)2(H2O)2](NO3)2 and guanosine of mol ratio1:1 in a neutral aqueous solution followed by careful purification with partial crystalization and recrystallizatlon from water at 0℃.The compound was characterized by elemental analysis,molecular weight determination,DTA,and C NMR spectroscopy and its formulawas found to be [8(GuoH-1)7 (OH)2] (NO3)7 8H2O.The isolation of the compound provides direct evidence for the intrastrand cross-linkage between cisplatin and DNA through N7,N1 atoms of two adjacent guanines.
The title Pt-Guo compound was synthesized and isolated by the reaction between cis- [Pt (NH3) 2 (H2O) 2] (NO3) 2 and guanosine of mol ratio 1: 1 in a neutral aqueous solution followed by careful purification with partial crystalization and recrystallizatlon from water at 0 ° C. The compound was characterized by elemental analysis, molecular weight determination, DTA, and C NMR spectroscopy and its formula was found to be [ 8 (GuoH-1) 2] (NO3) 7 8H2O. The isolation of the compound provides direct evidence for the intrastrand cross-linkage between cisplatin and DNA through N7, N1 atoms of two adjacent guanines.