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磺胺5甲氧嘧啶(Sulfamethoxydiainum)为国产新型长效磺胺药物。半衰期37小时,血内有效浓度维持时间较长,每日服药一次即可。其游离型和乙酰化物的溶解度较高,在肾内析出结晶的机会较少,易透入脑脊液中。此药与三甲氧苄胺嘧啶(TMP)合用,抗菌作用有显著增强。我们应用的增效磺胺5甲氧嘧啶(以下简称 TMP—SMD),是上海第二制药厂生产的片剂,每片含 SMD0.4,加 TMP0.08。我们于1975年上半年在郾城县及临汝
Sulfamethoxazole (Sulfamethoxydiainum) for the domestic new long-acting sulfa drugs. Half-life of 37 hours, the effective concentration of blood to maintain a longer time, once a day medication can be. Its free type and acetylation of high solubility in the kidney less crystallization opportunities, easy to penetrate the cerebrospinal fluid. The drug combined with trimethoprim (TMP), the antibacterial effect was significantly enhanced. We use the synergistic sulfa 5 methoxypyrimidine (hereinafter referred to as TMP-SMD), is the second Shanghai Pharmaceutical Factory production tablets, each containing SMD0.4, plus TMP0.08. We were in Yuncheng County and Linru in the first half of 1975