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本文作者通过前瞻性注册调查,分析了芬兰在1967～1976年间3002名采用各种避孕法的妇女娩出先天性畸形儿的情况,并与同时、同地未避孕的妇女娩出先天性畸形儿作配对对照,经过统计学卡方测验及相对危险性分析法试图观察口服避孕药对婴儿有无致畸的危险。调查记录的细目及随访内容两组完全相同。婴儿出生后一年内(包括600g以上的死产)发现的所有畸形,包括中枢神经系统缺陷、唐氏(Dow-n’s)综合征、骨胳畸形和口裂作为研究对象。结果表明:在3002名避孕妇女分娩的畸形儿
Through a prospective registration survey, the authors analyzed the situation of 3002 women with congenital malformations who were delivered by various contraceptive methods in Finland from 1967 to 1976 and compared them with congenital malformations delivered by women who were not contraceptive at the same time Control, after statistical chi-square test and relative risk analysis method to observe the oral contraceptives on the baby teratogenic risk. The details of the investigation and follow-up were identical between the two groups. All deformities, including central nervous system defects, Dow-n’s syndrome, skeletal malformations and bursa, that were found within one year of birth (including more than 600g of stillbirth) were studied. The results showed that 3 3002 contraceptive women gave birth to deformed children