论文部分内容阅读
目的探讨糖尿病患者血清中CD4~+CD25~+T细胞水平与胰岛素强化效果及患者临床预后的关系。方法选取本院2015年9月-2016年6月在院治疗的98例2型糖尿病患者作为观察组,另收集同期健康体检者60例作为对照组,检测患者血清中CD4~+CD25~+T细胞水平。采用Logistic回归分析探讨影响糖尿病患者临床预后的危险因素。结果对照组血清中CD4~+CD25~+T细胞明显低于观察组,而Th17细胞明显高于观察组,差异有统计学意义(P<0.05);CD4~+CD25~+T细胞高水平组观察组患者GLU、HOMA-IR、Hb A1C均高于CD4~+CD25~+T细胞低水平患者,而FIN水平低于CD4~+CD25~+T细胞低水平患者,差异有统计学意义(P<0.05);多因素分析提示,CD4~+CD25~+T细胞、BMI指数是糖尿病患者死亡的独立危险因素(P<0.05)。结论糖尿病早期胰岛素降糖有助于提高糖尿病患者治疗效果,血清中CD4~+CD25~+T细胞水平与患者免疫功能、临床降糖效果密切相关。
Objective To investigate the relationship between the level of CD4 ~ + CD25 ~ + T cells in serum of patients with diabetes mellitus and the effect of insulin fortification and the clinical prognosis of patients. Methods A total of 98 patients with type 2 diabetes mellitus treated in our hospital from September 2015 to June 2016 were selected as the observation group and another 60 healthy subjects were collected as the control group during the same period. Serum levels of CD4 ~ + CD25 ~ + T Cell level. Logistic regression analysis was used to explore the risk factors influencing the clinical prognosis of diabetic patients. Results The levels of CD4 ~ + CD25 ~ + T cells in the control group were significantly lower than those in the observation group, while the levels of Th17 cells in the control group were significantly higher than those in the observation group (P <0.05) The levels of GLU, HOMA-IR and Hb A1C in observation group were higher than those in low level of CD4 ~ + CD25 ~ + T cells, while FIN levels were lower than those in low level of CD4 ~ + CD25 ~ + T cells <0.05). Multivariate analysis suggested that CD4 ~ + CD25 ~ + T cells and BMI were independent risk factors for death in diabetic patients (P <0.05). Conclusion The early hypoglycemic effect of insulin in diabetic patients can improve the therapeutic effect of diabetic patients. The level of CD4 ~ + CD25 ~ + T cells in serum is closely related to the immune function and clinical hypoglycemic effect of patients.