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目的观察舒血宁联合硫酸镁治疗慢性肺原性心脏病急性加重期的临床疗效。方法将96例慢性肺原性心脏病急性加重期患者随机分为观察组和对照组,每组48例。对照组给予畅通气道、控制感染、纠正心衰、维持酸碱平衡等常规治疗,观察组在此基础上加用舒血宁和硫酸镁注射液静脉滴注治疗。两组疗程均为10 d。观察两组治疗前后临床疗效、血气分析及血流变学指标的变化。结果观察组治疗总有效率为91.7%,明显高于对照组的72.9%(P<0.05);治疗后观察组血气分析与血流变学指标改善程度明显优于照组(P均<0.05),且未发现明显不良反应。结论舒血宁联合硫酸镁可以明显改善慢性肺原性心脏病急性加重期患者的临床症状,改善血气分析和血液流变学指标。
Objective To observe the clinical effects of Shuxuening combined with Magnesium Sulfate in the treatment of acute exacerbation of chronic pulmonary heart disease. Methods 96 patients with acute exacerbation of chronic pulmonary heart disease were randomly divided into observation group and control group, 48 cases in each group. Control group was given smooth airway, infection control, correct heart failure, maintaining acid-base balance and other conventional treatment, the observation group on this basis with Shuxuening and magnesium sulfate injection intravenous infusion therapy. The two courses of treatment were 10 d. The clinical curative effect, blood gas analysis and hemorrheological changes of the two groups before and after treatment were observed. Results The total effective rate of observation group was 91.7%, which was significantly higher than that of control group (72.9%, P <0.05). After treatment, the improvement of blood gas analysis and hemorheology indexes in observation group was better than those in control group (all P <0.05) , And no obvious adverse reactions were found. Conclusion Shuxuening combined with magnesium sulfate can significantly improve the clinical symptoms of patients with acute exacerbation of chronic pulmonary heart disease, improve blood gas analysis and hemorheology.