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目的观察不同剂量整肠生对抗生素相关性腹泻的治疗作用。方法随机饮用头孢曲松钠诱导小鼠抗生素相关性腹泻和肠道菌群失调,然后灌胃不同剂量的整肠生,检测治疗后小鼠肠道菌群变化。结果在各给药组中,治疗第1天有53.33%~76.67%小鼠腹泻现象消失,2倍剂量组和4倍剂量组对失调肠道菌群恢复效果显著优于常规剂量组。消长曲线结果表明,整肠生在治疗第2天开始定植,连续服用可以增加肠道内菌落定植浓度,停药后逐渐消失,在肠道内的滞留时间为6~9 d。结论 2倍及更大剂量整肠生治疗头孢曲松诱导腹泻疗程更短,起效更快。
Objective To observe the therapeutic effect of antibiotic-associated diarrhea in different doses of intestine. Methods Ceftriaxone sodium was used to induce antibiotic-associated diarrhea and intestinal dysbacteriosis in mice, then gavage at different doses of gut, and changes of gut flora in mice were detected. Results In each treatment group, 53.33% ~ 76.67% of the diarrhea mice disappeared on the first day of treatment, and the recovery effects of the two groups were significantly better than those of the conventional dose group. The results of the growth and decline curve showed that the colon gut began colonization on the second day of treatment, continuous colonization could increase the concentration of colonization in the gut, and gradually disappeared after stopping the treatment. The residence time in the gut was 6 to 9 days. Conclusions 2-fold and larger dose of intestine treatment ceftriaxone-induced diarrhea treatment shorter, faster onset.