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目的:探讨二肽基肽酶Ⅳ(CD26/DPPⅣ)在子宫内膜样腺癌的表达及其意义。方法:用免疫组织化学SABC法,分别检测32例子宫内膜样腺癌及10例正常子宫内膜中CD26/DPPⅣ的表达。结果:CD26/DPPⅣ在正常增殖期子宫内膜中低表达,在正常分泌期子宫内膜中表达增加。在子宫内膜样腺癌中随细胞分化程度降低、恶性程度升高其表达水平降低。诊断子宫内膜样腺癌的敏感性、特异性及诊断准确率,CD26/DPPⅣ分别为71.9%,10.0%及57.1%。结论:CD26/DPPⅣ免疫组化染色可以辅助常规的病理检查进行子宫内膜样腺癌的鉴别诊断,对子宫内膜样腺癌的恶性程度的判断很有意义,但单独作为子宫内膜样腺癌的标志物效果并不理想。对于子宫内膜样腺癌的侵袭、淋巴结转移及预后的判断可能无明显价值。
Objective: To investigate the expression of dipeptidyl peptidase Ⅳ (CD26 / DPP Ⅳ) in endometrioid adenocarcinoma and its significance. Methods: Immunohistochemical SABC method was used to detect the expression of CD26 / DPPⅣ in 32 cases of endometrioid adenocarcinoma and 10 cases of normal endometrium respectively. Results: CD26 / DPPⅣ was overexpressed in endometrium during normal proliferative phase and increased in endometrium during normal secretory phase. In endometrioid adenocarcinoma with the degree of cell differentiation decreased, the degree of malignancy decreased its expression level. The sensitivity, specificity and accuracy of diagnosis of endometrioid adenocarcinoma were 71.9%, 10.0% and 57.1% respectively. Conclusion: The immunohistochemical staining of CD26 / DPPⅣ can assist the routine pathological examination in the differential diagnosis of endometrial adenocarcinoma. It is of great significance to judge the degree of malignancy of endometrial adenocarcinoma, but as endometrioid adenocarcinoma alone The effect of cancer markers is not ideal. For endometrioid adenocarcinoma invasion, lymph node metastasis and prognosis may not have a clear value.