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目的评估梅毒血浆反应素快速试验(RPR)与梅毒螺旋体明胶颗粒凝集试验(TPPA)检测对梅毒诊断和疗效的价值分析。方法对300例梅毒患者、100例非梅毒患者以及50例正常人进行RPR与TPPA进行联合检测并进行分析。结果 172例梅毒Ⅰ期患者RPR和TPPA的阳性率分别为83.1%和100.0%,117例梅毒Ⅱ期RPR和TPPA的阳性率均为100.0%,11例潜伏期梅毒的RPR和TPPA的阳性率分别为84.6%和100.0%,100例非梅毒患者的RPR和TPPA的阳性率分别为3.0%和0;50例健康体检者的RPR和TPPA的阳性率均为0。结论 RPR和TPPA都是梅毒诊断快速有效的方法,但是TPPA作为确诊试验特异性和灵敏度均明显要高于RPR,但在对疗效观察价值上RPR则又明显好于TPPA。
Objective To evaluate the value of the syphilis rapid response test (RPR) and syphilis spirochete gelatin particle agglutination test (TPPA) in the diagnosis and treatment of syphilis. Methods 300 cases of syphilis patients, 100 cases of non-syphilis patients and 50 normal subjects were detected by RPR and TPPA and analyzed. Results The positive rates of RPR and TPPA in 172 cases of syphilis stage Ⅰ were 83.1% and 100.0% respectively. The positive rates of RPR and TPPA in 117 cases of syphilis stage Ⅱ were 100.0%. The positive rates of RPR and TPPA in 11 cases of latent syphilis were 84.6% and 100.0% respectively. The positive rates of RPR and TPPA in 100 non-syphilis patients were 3.0% and 0 respectively. The positive rates of RPR and TPPA were all 0 in 50 healthy subjects. Conclusion Both RPR and TPPA are rapid and effective methods for the diagnosis of syphilis. However, the specificity and sensitivity of TPPA as a diagnostic test are significantly higher than those of RPR, but RPR is significantly better than that of TPPA in evaluating the therapeutic effect.