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目的:探讨盐酸氨溴索联合N-乙酰半胱氨酸(NAC)对慢性阻塞性肺疾病急性加重期(AECOPD)的治疗作用。方法:将46例AECOPD患者随机分为观察组和对照组,对照组23例常规治疗,单用盐酸氨溴索;治疗组在以上常规治疗的基础上加用N-乙酰半胱氨酸泡腾片(0.6g,1次/d),疗程2周,观察临床疗效及肺功能变化。结果:治疗组较对照组临床症状改善明显,肺功能(FEV1及FEV1/FVC%)治疗前后比较差异有显著性(P<0.05)。结论::盐酸氨溴索联合NAC对AECOPD有较显著的治疗作用。
Objective: To investigate the therapeutic effect of ambroxol hydrochloride combined with N-acetylcysteine (NAC) on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 46 patients with AECOPD were randomly divided into observation group and control group. The control group was treated routinely with 23 cases of ambroxol hydrochloride alone. The treatment group was treated with N-acetylcysteine effervescent Tablets (0.6g, 1 / d) for 2 weeks to observe the clinical efficacy and changes in lung function. Results: Compared with the control group, the clinical symptoms improved obviously in the treatment group. The pulmonary function (FEV1 and FEV1 / FVC%) had significant difference before and after treatment (P <0.05). Conclusion: Ambroxol hydrochloride combined with NAC has a significant therapeutic effect on AECOPD.