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目的观察埃索美拉唑对胃食管反流病(GERD)患者食管下段鳞状上皮细胞间隙(DIS)的改变。方法随机选取5名健康志愿者测食管黏膜DIS,做为正常参考值;选6名非糜烂性GERD(NERD)患者、5名反流性食管炎(RE)患者作为治疗组观察对象,经埃索美拉唑治疗3个月,在齿状线上3～5cm黏膜处取活检,观察DIS与治疗前比较是否改变,并对其进行统计学分析。结果 3个月治疗后NERD组5/6的患者DIS恢复正常(83.3%),RE组4/5的患者DIS恢复正常(80%)。DIS未恢复正常的2例患者临床症状未完全消失。结论 GERD患者经埃索美拉唑治疗3个月后DIS改变显著,临床症状改善明显。
Objective To observe the changes of esophagone in esophageal reflux disease (GERD) patients with lower esophageal squamous cell gap (DIS) changes. Methods Five healthy volunteers were randomly selected to measure DIS of esophageal mucosa as a normal reference value. Six non-erosive GERD (NERD) patients and five patients with reflux esophagitis (RE) were selected as the treatment group. Somelazole treatment for 3 months, in the dentate line 3 ~ 5cm mucosa at the biopsy to observe the DIS and before treatment whether the change, and its statistical analysis. Results After 5 months of treatment, the DIS of 5/6 patients in the NERD group returned to normal (83.3%), and the DIS of 4/5 patients in the RE group returned to normal (80%). DIS did not return to normal 2 patients clinical symptoms have not completely disappeared. Conclusions After 3 months of esomeprazole treatment, the changes of DIS in GERD patients were significant and the clinical symptoms improved significantly.