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目的考察不同品种枳实对心血管和呼吸系统的作用差异。方法采用麻醉大鼠,经十二指肠给予不同产地枳实提取物,给药剂量为4.2、2.1g原药材/kg,给药后连续4h观察大鼠血压、呼吸及心电图情况。结果与对照组比较,酸橙大剂量组及甜橙大、小剂量组动物呼吸幅度于药后20min一过性升高,后均恢复正常,各实验组之间差异均无统计学意义;实验期间未观察到枳实对心电的影响,各实验组之间差异无统计学意义;酸橙对血压的影响较显著,与对照组比较,酸橙大剂量组动物收缩压、舒张压及平均血压的降低于药后40、60、80min差异均有统计学意义,小剂量组于药后60min也有显著差异,提示酸橙确有一定的降压作用,作用持续时间可达2h以上。甜橙对血压的影响并不明显,酸橙组与甜橙组比较有显著差异。结论我国药典规定的两种枳实对呼吸系统有一过性的兴奋作用,对心脏的直接作用不明显,但酸橙的降压作用明显优于甜橙,在临床使用中应给予注意。
Objective To investigate the effects of different varieties of Citrus aurantium on cardiovascular and respiratory system. Methods Anesthetized rats were given duodenum extract of Fructus Aurantii from different areas. The dosage was 4.2 and 2.1g of crude drug / kg. The blood pressure, respiration and electrocardiogram were observed for 4 hours after administration. Results Compared with the control group, the respiration rate of the large dose group and the large dose group of the orange juice increased transiently after 20 minutes and returned to normal after the treatment, and there was no significant difference between the experimental groups During this period, the effect of citrus aurantium on ECG was not observed, and there was no significant difference between the experimental groups. The effect of lime on blood pressure was significant. Compared with the control group, the systolic blood pressure, diastolic blood pressure and mean The decrease of blood pressure was statistically significant at 40, 60, and 80 min after drug administration. There was also a significant difference at 60 min after drug administration in the low-dose group, suggesting that the acid orange does have certain antihypertensive effect with a duration of up to 2 h. The effect of sweet orange on blood pressure is not obvious, there is a significant difference between the orange group and the sweet orange group. Two kinds of citrus aurantium provisions conclusions of pharmacopoeia of a transient respiratory system stimulant, a direct effect on the heart is not obvious, but the antihypertensive effect of lime was superior to orange, in clinical use should be given attention.