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目的研究盐酸度洛西汀胶囊(抗抑郁药)在健康人体内的药代动力学。方法 10名健康受试者,男女各半,单剂量口服盐酸度洛西汀肠溶胶囊60 mg。用高效液相色谱法测定血浆中度洛西汀的浓度;用DAS 2.0计算药代动力学参数。结果度洛西汀的主要药代动力学参数:Cmax为(58.74±7.25)μg.L-1,Tmax为(6.10±0.74)h,t1/2(ke)为(15.79±1.17)h,AUC0-72为(1423.01±157.29)μg.h.L-1。结论度洛西汀在健康人体内符合一级吸收的一室模型。
Objective To study the pharmacokinetics of duloxetine hydrochloride capsules (antidepressants) in healthy volunteers. Methods Ten healthy subjects, male and female, were given a single oral dose of 60 mg duloxetine hydrochloride enteric-coated capsules. Plasma concentrations of duloxetine were determined by high performance liquid chromatography; pharmacokinetic parameters were calculated using DAS 2.0. Results The main pharmacokinetic parameters of duloxetine were Cmax (58.74 ± 7.25) μg.L-1, Tmax (6.10 ± 0.74) h and t1 / 2 (ke) -72 was (1423.01 ± 157.29) μg.hL-1. Conclusions Duloxetine is a one-compartment model that conforms to primary absorption in healthy humans.