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本文用３２ＰＨＢＶ－ＤＮＡ探针检测乙型肝炎（乙肝）患儿及病毒携带者尿ＨＢＶ－ＤＮＡ共７８例，阳性率为１４．１％（１１／７８）。结果表明乙肝病毒可经肾小球滤过，在尿中出现具有传染性。同时检测了上述患儿尿三项蛋白，即β２微球蛋白（β２ＭＧ）、白蛋白（Ａｌｂ）和免疫球蛋白Ｇ（ＩｇＧ），尿Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶（ＮＡＧ）及肾功能等，经与对照组比较，乙肝患儿及携带者尿β２Ｍ和Ａｌｂ均有不同程度升高，而尿ＮＡＧ正常。对尿蛋白异常的患儿随访３～６个月，基本恢复正常，提示蛋白尿可能为ＨＢＶ致肾损害的早期表现．
In this paper, HBV DNA was detected in 78 patients with HBV and HBV carriers by 32 PHBV-DNA probe, the positive rate was 14.1% (11/78). The results show that hepatitis B virus can be glomerular filtration, appears infectious in the urine. At the same time, the urinary tripeptides (β2MG, Alb and IgG) and urine N-acetyl-β-D-glucosaminidase (NAG) And renal function, compared with the control group, children with hepatitis B and carrier urine β2M and Alb increased to varying degrees, while urinary NAG normal. Urinary protein abnormalities in children followed up for 3 to 6 months, returned to normal, suggesting that proteinuria may be an early manifestation of renal damage caused by HBV.