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应用中药川芎嗪等治疗58例胎儿宫内生长迟缓（IUGR）患者，分为川芎嗪治疗组47例、氨基酸治疗组11例。结果显示治疗后IUGR的病理生理变化接近或恢复正常，脐动、静脉及子宫动脉的TAV和Q上升，S／D值、RI等下降；母血E3、HPL上升，6-keto-PGF1a水平增高，TXB2／6-keto-PGF1a比值下降，川芎嗪组治疗总有效率达95．74％，显著优于氨基酸组（81．82％），P＜0．05，差异有显著性意义。研究表明川芎嗪能改善胎盘功能，纠正子宫胎盘胎儿血液循环障碍，是治疗IUGR的有效药物。
Patients with 58 cases of intrauterine growth retardation (IUGR) treated with the traditional Chinese medicine ligustrazine were divided into the tetramethylpyrazine group of 47 cases and the amino acid group of 11 cases. The results showed that the pathophysiological changes of IUGR were close to or normal after treatment, TAV and Q of umbilical artery, vein and uterine artery increased, S/D value, RI, etc. decreased; maternal blood E3, HPL increased, and 6-keto-PGF1a levels increased. The ratio of TXB2/6-keto-PGF1a decreased, and the total effective rate of TMP group was 95.74%, which was significantly better than that of amino acid group (81.82%), P<0.05. The difference was significant. Studies have shown that ligustrazine can improve placental function, correct uteroplacental fetal blood circulation disorders, is an effective drug for the treatment of IUGR.