Immunohistochemical Analysis of Omi/HtrA2 Expression in Prostate Cancer and Benign Prostatic Hyperpl

• 作 者: HU Xiaoyong CHEN Xiaochun PING Hao CHEN Zhaohui ZENG Fuqing LU Gongcheng
• 机 构: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Te
• 出 处: 华中科技大学学报（医学英德文版）
• 发表日期: 2005年6期
• 关键词: Omi/HtrA2 serine protease prostate cancer benign prostatic hyperplasia apoptosis

To study the expression and significance of the serine protease Omi/HtrA2 in prostate cancer and benign prostatic hyperplasia. The expression of Omi/HtrA2 was assayed by means of immunohistochemical technique in 41 prostate cancer (Cap), 20 benign prostatic hyperplasia (BPH) and 10 normal prostate (NP) specimens. Omi/HtrA2 expression was positive in 30 (73.17%) prostate cancer specimens, and the positive rate of Omi/HtrA2 was lower in well differentiated than in poorly and moderately differentiated groups (P＜0.05). By contrast, the cells in normal prostate and benign prostatic hyperplasia groups showed no or weak expression of Omi/HtrA2.Prostate cancer cells in vivo may need Omi/HtrA2 expression for apoptosis, and that Omi/HtrA2expression might be involved in prostate cancer development.