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目的探讨持续静脉滴注速尿治疗充血性心力衰竭(CHF)的药效学及其对生理平衡的影响是否优于一次性注射治疗。方法将30例NYHA心功能Ⅲ~Ⅳ级CHF患者随机分为持续静脉滴注组(静滴组,15例)和一次静脉注射组(静注组,15例)。静滴组在持续静脉滴注速尿30mg后注射10mg,静注组一次性注射40mg,持续3天。治疗前后分别评价心功能及血生化指标,并计算每日尿量和尿K+、Na+、C l-量。结果静滴组每日尿量和尿K+、Na+、C l-量均明显大于静注组,尤其是在治疗的第一、二天,生化指标两组无明显差异。结论持续静脉滴注速尿治疗CHF在药效学方面明显优于静脉注射方式,并可提高肾脏对速尿的敏感性,延缓耐受性的产生。
Objective To investigate the pharmacodynamics of continuous intravenous drip furosemide in patients with congestive heart failure (CHF) and its effect on physiological balance better than one-time injections. Methods Thirty newborns with NYHA class Ⅲ ~ Ⅳ CHF were randomly divided into continuous intravenous drip (intravenous drip group, 15 cases) and intravenous injection group (intravenous group, 15 cases). Intravenous drip group in the sustained intravenous furosemide 30mg after injection of 10mg, intravenous injection group 40mg, for 3 days. Before and after treatment, respectively, evaluation of cardiac function and blood biochemical indicators, and calculate the daily urine output and urine K +, Na +, C l-volume. Results The daily urine volume and urinary K +, Na + and C l -amounts in the intravenous drip group were significantly greater than those in the intravenous group, especially in the first and second days of treatment, there was no significant difference in biochemical indexes between the two groups. Conclusion Continuous intravenous furosemide treatment of CHF in pharmacodynamics was superior to intravenous injection, and can improve the sensitivity of the kidneys to furosemide, delayed the production of tolerance.