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目的:研究宫颈癌化疗前后端粒酶的变化。方法:采用免疫组化SAB法检测35例手术切除的宫颈癌石蜡包埋组织,术前行PF方案化疗,检测化疗前后端粒酶的表达。结果:(1)端粒酶在宫颈癌中的阳性表达率为91.4%,正常宫颈组织中无阳性表达;(2)化疗前端粒酶阳性率91.4%,化疗后端粒酶的阳性率65.7%,差异有统计学意义(P<0.01)。结论:化疗后端粒酶的活性降低,可能成为预测宫颈癌化疗及预后的重要指标。
Objective: To study the changes of telomerase before and after cervical cancer chemotherapy. Methods: 35 cases of paraffin-embedded cervical cancer tissues were detected by immunohistochemical SAB method. PF regimen chemotherapy was performed preoperatively to detect the expression of telomerase before and after chemotherapy. Results: (1) The positive rate of telomerase in cervical cancer was 91.4% and no positive expression in normal cervical tissue. (2) The positive rate of telomerase before chemotherapy was 91.4%, the positive rate of telomerase after chemotherapy was 65.7% , The difference was statistically significant (P <0.01). Conclusion: The decrease of telomerase activity after chemotherapy may be an important index to predict the prognosis of cervical cancer.