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应用免疫组织化学方法检测２３０例胃粘膜病变标本中增殖细胞核抗原（ＰＣＮＡ）的表达，计算细胞增殖指数（ＬＩ），探讨细胞增殖分级及其在胃癌发生中的意义。结果显示正常或慢性浅表性胃炎、伴肠化生慢性萎缩性胃炎、伴异型增生慢性萎缩性胃炎以及胃腺癌的ＬＩ逐渐增高，差异非常明显（Ｐ＜０．０１）；反映细胞增殖状态的ＬＩ分级与各类胃粘膜病变具有较好的相关性，Ⅰ级为正常胃粘膜，Ⅱ级为胃粘膜良性病变，Ⅲ级为胃粘膜癌前病变，Ⅳ级为胃癌，提示胃粘膜上皮细胞的增殖状态可作为评价胃癌发生风险的一项有效指标，胃粘膜病变ＬＩ分级具有较好的临床应用前景。
The expression of proliferating cell nuclear antigen (PCNA) in 230 cases of gastric mucosal lesions was detected by immunohistochemical method. The cell proliferation index (LI) was calculated to investigate the proliferation and grading of gastric cancer and its significance in the development of gastric cancer. The results showed that the normal or chronic superficial gastritis, chronic atrophic gastritis with intestinal metaplasia, chronic atrophic gastritis associated with atypical hyperplasia, and gastric adenocarcinoma LI gradually increased, the difference was very significant (P <0.01); reflect the state of cell proliferation The LI classification had a good correlation with gastric mucosal lesions. Grade I was normal gastric mucosa, grade II was benign gastric lesions, grade III was gastric precancerous lesions, grade IV was gastric carcinoma, suggestive of gastric mucosal epithelial cells. Proliferation status can be used as an effective index to evaluate the risk of gastric cancer. LI classification of gastric mucosal lesions has good clinical application prospects.