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本文研究３２例胃、十二指肠溃疡患者血浆、胃液及胃、十二指肠溃疡缘与正常胃粘膜组织中内皮素Ⅰ的水平，并以１９例健康人作对照。结果表明：胃溃疡患者血浆内皮素Ⅰ水平为４．４８±０．７８ｐｇ／ｍｌ，明显高于健康对照组血浆水平２．５６±０．１７ｐｇ／ｍｌ，Ｐ＜０．０５。胃溃疡缘组织中内皮素Ⅰ含量为４１．６３±４．３６ｐｇ／ｍｇ，明显高于自身正常胃粘膜２１．８４±１．７３ｐｇ／ｍｇ和健康对照组内皮素Ⅰ含量２１．７８±１．６８ｐｇ／ｍｇ，Ｐ值均＜０．００１。提示内皮素Ⅰ可能作为局部因素参与胃溃疡的形成，并说明胃溃疡患者有血管收缩和舒张因子的代谢不平衡。而十二指肠溃疡患者血浆、胃液、组织中内皮素Ⅰ水平与健康对照组无明显差异，提示内皮素Ⅰ在十二指肠溃疡发病中并不起重要作用。
In this paper, 32 cases of gastric ulcer in patients with plasma, gastric juice and gastric, duodenal ulcer edge and normal gastric mucosa tissue levels of endothelin Ⅰ, and 19 healthy controls. The results showed that plasma endothelin Ⅰ level in gastric ulcer patients was 4.48 ± 0.78pg / ml, which was significantly higher than that in healthy controls (2.56 ± 0.17pg / ml, P <0.05). The content of endothelin Ⅰ in gastric ulcer tissue was 41.63 ± 4.36pg / mg, which was significantly higher than 21.84 ± 1.73pg / mg in normal gastric mucosa and 21.78 ± 1 in healthy control group. 68pg / mg, P <0.001. These results suggest that endothelin-1 may participate in the formation of gastric ulcer as a local factor and explain the metabolic imbalance of vasoconstrictor and relaxation factor in patients with gastric ulcer. The plasma endotoxin level in plasma, gastric juice and tissue of patients with duodenal ulcer had no significant difference with healthy control group, suggesting that endothelin Ⅰ does not play an important role in the pathogenesis of duodenal ulcer.