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本文首次应用国产乳果糖—氢气呼吸试验(BHT),监测了16例肝硬变患者小肠传递时间(SBTT)及小肠细菌过度生长(BOG).肝硬变SBTT为106.8±24.6min,较正常组(80.6±28.3min)显著延迟,P<0.01.其中腹水组为118.4±19.8min,较无腹水组(88.6±20.3min)显著延迟,P<0.01.BOG阳性率为37.5%,而正常组无1例阳性.6例BOG均伴有SBTT延迟,其中5例合并腹水.6例BOG服用灭滴灵1周后全部转阴.乳果糖-BHT可同时监测SBTT及BOG,故对肝硬变尤为适用.实为临床提供一种方便、可靠的检测手段.
In this paper, we first applied the domestic lactulose-hydrogen breath test (BHT) to monitor the intestinal transit time (SBTT) and intestinal bacterial overgrowth (BOG) in 16 patients with cirrhosis.The SBTT of cirrhosis was 106.8 ± 24.6min, (80.6 ± 28.3min), P <0.01. The ascites group was 118.4 ± 19.8min, which was significantly delayed compared with the ascites group (88.6 ± 20.3min), P <0.01.The positive rate of BOGO was 37.5% 1 cases were positive.The 6 cases of BOG are associated with SBTT delay, of which 5 cases with ascites.The 6 cases of BOG taking meclizine after 1 week all negative.Lactulose-BHT can simultaneously detect SBTT and BOG, so especially for cirrhosis Applicable. In fact, to provide a convenient and reliable clinical testing means.