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目的探讨腰椎穿刺脑脊液置换联合鞘内给药治疗蛛网膜下腔出血(SAH)的临床效果。方法将我院收治的58例SAH患者按随机数字表法分为两组,常规组给予常规内科保守治疗,置换组在常规组基础上采用腰椎穿刺脑脊液置换联合鞘内给药治疗,观察比较两组的临床指标变化、主要并发症发生情况及临床疗效。结果置换组总有效率明显高于常规组(P<0.05),头痛缓解、意识障碍持续及脑脊液恢复正常时间置换组较常规组明显缩短(P<0.05),置换组脑血管痉挛、脑积水发生率低于常规组(P<0.05)。结论腰椎穿刺脑脊液置换联合鞘内给药疗效好,更好地预防并发症发生,可作为治疗SAH的有效方法。
Objective To investigate the clinical effect of lumbar puncture and cerebrospinal fluid replacement combined with intrathecal administration on subarachnoid hemorrhage (SAH). Methods Fifty-eight patients with SAH admitted to our hospital were divided into two groups according to the random number table. The conventional group was given routine conservative treatment. The replacement group was treated with lumbar puncture and cerebrospinal fluid replacement combined with intrathecal administration on the basis of conventional group. Group clinical changes, the main complications and clinical efficacy. Results The total effective rate in the replacement group was significantly higher than that in the conventional group (P <0.05). The headache relief, disturbance of consciousness and normal time of cerebrospinal fluid replacement in the replacement group were significantly shorter than those in the conventional group (P <0.05). Cerebral vasospasm and hydrocephalus The incidence was lower than the conventional group (P <0.05). Conclusions Lumbar puncture combined with cerebrospinal fluid replacement and intrathecal administration has a good curative effect and better prevention of complications, which can be used as an effective method for the treatment of SAH.