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本文提出了口服氨茶诚后监测两点血药浓度制订个体化给药方案的方法,用药代动力学原理推导出预测氨茶碱口服维持量的数学公式为 Dm。Dm=2Css×X(?)(?)(?)Cr×(InCr/2-InCr)/C~2_(r/2),并用我院10例 COPD(慢性肺阻塞性肺病)患者口服氨茶碱后的血药浓度值验证了建立 Dm 模型的可靠性。此模型经临床应用效果满意,7例 COPD 患者用此法预测维持量后,测得其稳态平均血药浓度为 Css=10.88±0.72μg/ml,本法消去了制剂生物利用度和表观分布容积两个参数,使数学模型变得简单,并且具有取血次数少,应用灵活的持点。
This paper presents a method of monitoring the blood concentration of two points of oral ammonia after the establishment of individualized drug delivery program, and the mathematical formula for predicting oral maintenance of aminophylline is derived from the principle of pharmacokinetics. Dm = 2Css × X (?) Cr × (InCr / 2-InCr) / C ~ 2_ (r / 2) and in our hospital 10 patients with COPD (chronic obstructive pulmonary disease) The plasma concentrations of base after the test confirmed the reliability of the Dm model. The model was satisfactory in clinical application. After 7 patients with COPD were used to predict the maintenance dose, the steady-state average plasma concentration was measured as Css = 10.88 ± 0.72μg / ml. This method eliminated the bioavailability and apparent The two parameters of the volume of distribution make the mathematical model simple, and have the advantages of taking less blood and applying flexible points.