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目的探讨T淋巴瘤侵袭转移诱导因子1的表达与甲状腺癌侵袭转移的关系。方法采用免疫组织化学S-P法检测Tiam1在89例甲状腺癌及其淋巴结转移癌的石蜡组织标本中的表达。结果淋巴结转移癌组织中Tiam1的表达显著高于甲状腺癌原发灶中的表达(P<0.05);伴发转移的甲状腺癌组织比未发生转移的甲状腺癌组织的Tiam1表达明显增强(P<0.05);甲状腺髓样癌、未分化癌组织中Tiam1的表达显著高于乳头状癌、滤泡癌中的表达(P<0.05);高临床分期(III、IV期)甲状腺癌组织中的Tiam1表达明显高于低临床分期(I、II期)中的表达(P<0.05)。结论Tiam1的表达与甲状腺癌的侵袭转移密切相关,提示Tiam1在甲状腺癌的侵袭转移中起重要作用。
Objective To investigate the relationship between the expression of invasion and metastasis inducing factor 1 (T lymphoma) and the invasion and metastasis of thyroid cancer. Methods Immunohistochemical S-P method was used to detect the expression of Tiam1 in 89 cases of thyroid carcinoma and lymph node metastasis of paraffin tissue specimens. Results The expression of Tiam1 in lymph node metastasis was significantly higher than that in primary thyroid carcinoma (P <0.05). The expression of Tiam1 in thyroid carcinoma with metastasis was significantly higher than that in non-metastatic thyroid carcinoma (P <0.05) ). The expression of Tiam1 in medullary thyroid carcinoma and undifferentiated carcinoma was significantly higher than that in papillary carcinoma and follicular carcinoma (P <0.05). The expression of Tiam1 in thyroid carcinoma with high clinical stage (stage III and IV) Significantly higher than in low clinical stage (stage I, II) (P <0.05). Conclusion The expression of Tiam1 is closely related to the invasion and metastasis of thyroid carcinoma, suggesting that Tiam1 plays an important role in the invasion and metastasis of thyroid carcinoma.