Metabolic engineering of Streptomyces coelicolor for enhanced prodigiosins （RED） production

• 作 者: Panpan Liu Hong Zhu Guosong Zh
• 机 构: KeyLaboratoryofSyntheticBiology,UniversityofChineseAcademyofSciences,jiangsuNationalSynergeticInnova
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2017年9期
• 关键词: 天蓝色链霉菌 生产菌株 灵菌红素 代谢工程 生物合成基因簇 染色体整合 次生代谢产物 突变行为 Streptomyces coelicolor prodigi
• 基金项目: supported by the National Natural Science Foundation of China（31430004,31421061,31630003,31370081 and 31570072）, the Science and Technology Commission of Shanghai Municipality（16490712100）

Bacterial prodigiosins are red-colored secondary metabolites with multiple activities,such as anticancer,antimalarial and immunosuppressive,which hold great potential for medical applications.In this study,dramatically enhanced prodigiosins(RED) productio