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目的:癌症患者的预后不仅取决于肿瘤相关因素，还取决于宿主相关因素，特别是全身炎性反应。基于中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）及淋巴细胞与单核细胞比值（LMR）构建预测胃癌（GC）根治性切除术后患者生存时间的系统炎性标志物评分（SIMS）。方法:选取青海省交通医院、青海省红十字医院2011年1月至2017年1月行根治性切除术治疗的205例GC患者。术前收集患者NLR、PLR及LMR。采用受试者工作特征（ROC）曲线获得NLR、PLR、LMR最佳截断值并构建SIMS。单因素及多因素Cox风险比例模型分析SIMS的临床价值。结果:所有患者均获得随访，随访时间20 ~ 65（63.47 ± 10.36）个月，中位生存时间56个月。1年病死率6.3%，3年病死率26.2%，5年病死率34.6%。NLR、PLR、LMR的曲线下面积（AUC）分别为0.745、0.805、0.866，最佳截断值分别为3.11、144、3.34。NLR>3.11、PLR>144、LMR ≤ 3.34患者的病死率高于NLR ≤ 3.11、PLR ≤ 114、LMR>3.34的患者（n χ2 = 10.491、14.658、38.765，n P 144, LMR ≤ 3.34 was higher than that of patients with NLR ≤ 3.11, PLR ≤ 114, LMR > 3.34 ( n χ2 = 10.491, 14.658 and 38.765; n P<0.01); there were differences in survival curves among different groups of NLR, PLR, LMR (n P < 0.05). The survival curves of different scores of SIMS were different ( n P < 0.05). Age ( n HR = 1.358, 95% n CI 1.153 to 1.599), T stage-Tn 3 (n HR = 2.739, 95% n CI 1.200 to 6.248), T stage-Tn 4 (n HR = 3.013, 95% n CI 1.312 to 6.920), N stage-Nn 2 (n HR = 5.832, 95% n CI 2.974 to 11.455), pathological stage Ⅲ (n HR = 2.962, 95% n CI 1.835 to 4.646), lymphovascular invasion (n HR = 1.813, 95% n CI 1.274 to 3.642), SIMS-1 (n HR = 7.065, 95% n CI 4.673 to 10.692), SIMS-2 (n HR = 7.885, 95% n CI 4.991 to 12.435), SIMS-3 (n HR = 8.365, 95% n CI 5.635 to 3.485) were the independent risk factors of GC patients′ death (n P < 0.05).n Conclusions:This study successfully constructs Sims and confirms that preoperative Sims is a relatively easy, easy to obtain and low-cost prognosis index for GC patients, which can be used to evaluate the survival time of GC patients before operation.