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目的：为了研究血清Ⅳ型胶原和透明质酸在肝硬化患者中的变化。方法：检测了４２例肝硬化患者血清Ⅳ型胶原和透明质酸的水平。结果：Ⅳ型胶原和透明质酸在Ｃｈｉｌｄ－ｐｕｇｈＣ级组最高，Ｂ级组次之，Ａ级组最低。结论：血清Ⅳ型胶原和透明质酸可能作为反应肝硬化程度和判断肝功能状况的辅助指标。
Objective: To investigate the changes of serum type Ⅳ collagen and hyaluronic acid in cirrhotic patients. Methods: The serum levels of type Ⅳ collagen and hyaluronic acid in 42 patients with cirrhosis were detected. Results: Type Ⅳ collagen and hyaluronic acid were highest in Child-pughC group, followed by group B and lowest in group A. Conclusion: Serum type Ⅳ collagen and hyaluronic acid may be used as secondary indicators to evaluate the degree of liver cirrhosis and determine the status of liver function.