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目的探究左西孟旦与心脏再同步治疗(CRT)对慢性心力衰竭患者(CHF)心脏功能和左心室收缩同步性的影响。方法选取60例南阳医学高等专科学校第一附属医院慢性心力衰竭患者按随机数字表法分为对照组和观察组,每组30例。对照组患者给予常规抗心衰治疗及心脏再同步治疗,观察组在对照组基础上给予左西孟旦治疗,两组患者均持续治疗4周。于治疗前、治疗后比较两组左室射血分数(LVEF)、每博心输出量(SV)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)及心室收缩同步性(ΔTs)。结果治疗后,两组LVEF均较治疗前显著增大,差异有统计学意义(P<0.05),两组间LVEF比较差异无统计学意义(P>0.05);两组SV较治疗前均明显增大,且观察组大于对照组(P<0.05);两组LVEDD、LVESD较治疗前均明显缩小(P<0.05),但两组间差异无统计学意义(P>0.05)。治疗后,两组ΔTs均明显改善,且观察组较对照组改善更显著(P<0.05)。结论左孟西旦联合CRT治疗CHF,可明显改善患者心功能及心室收缩同步性,治疗效果优于单一CRT治疗。
Objective To investigate the effect of levosimendan and cardiac resynchronization therapy (CRT) on the cardiac function and the systolic left ventricular systolic function in patients with chronic heart failure (CHF). Methods Sixty cases of chronic heart failure in the First Affiliated Hospital of Nanyang Medical College were divided into control group and observation group according to random number table method, with 30 cases in each group. Patients in the control group were given routine anti-heart failure treatment and cardiac resynchronization therapy. The observation group was given levosimendan on the basis of the control group, and both groups were treated for 4 weeks. Before treatment and after treatment, LVEF, SV, LVEDD, LVESD and ventricular systolic (LVEDD) were compared between the two groups (left ventricular ejection fraction, left ventricular end-diastolic diameter ΔTs). Results After treatment, LVEF in both groups was significantly increased compared with that before treatment (P <0.05), and there was no significant difference in LVEF between the two groups (P> 0.05) (P <0.05). The LVEDD and LVESD of the two groups were significantly decreased (P <0.05), but there was no significant difference between the two groups (P> 0.05). After treatment, ΔTs were significantly improved in both groups, and the observation group improved more significantly than the control group (P <0.05). Conclusion Levoxetine combined with CRT in the treatment of CHF, can significantly improve the patient’s cardiac function and ventricular systolic synchronization, the treatment effect is better than single CRT treatment.