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尽管病原体能通过它们本身的方式入侵机体的许多部分,然而宿主对病原体的感应器——Toll-样受体(Toll-like receptors,TLRs)也能以广泛的、显著的方式在免疫细胞表达,以防御和应对病原体的入侵.目前的研究表明,TLRs不仅在天然免疫系统的效应细胞表达,以介导即刻的抗病原体反应,并且也在适应性免疫系统的T-,B-淋巴细胞表达,提示TLRs直接调节了适应性免疫反应.鉴于TLRs多种效应研究的快速进展,本文将论及TLRs的一些主要性质及它们对T-,B-淋巴细胞的直接作用,并对最近的发现和潜在的治疗应用进行了讨论.总之,不断增多的证据支持这样一种概念,即TLR的激活不仅属于天然免疫,而且也属于包括直接调节T-,B-淋巴细胞功能在内的适应性免疫.
Although pathogens can invade many parts of the body by their own means, host-to-pathogen sensors, such as toll-like receptors (TLRs), can also be expressed in a wide range of significant ways in immune cells, To prevent and counter the invasion of pathogens.Recent studies have shown that TLRs are not only expressed in the effector cells of the innate immune system to mediate an immediate anti-pathogen response but also in T-, B-lymphocyte expression in the adaptive immune system, Suggesting that TLRs directly regulate the adaptive immune response.In view of the rapid progress of multiple effects of TLRs, this article will discuss some of the main properties of TLRs and their direct effect on T-, B-lymphocytes, and the recent findings and potential In summary, increasing evidence supports the notion that activation of TLRs is not only natural but also includes adaptive immunity that directly regulates T- and B-lymphocyte function.