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在质量浓度为 0 .5g/L的酒石酸乙醇溶液中 ,阿司匹林、非那西汀、咖啡因和苯巴比妥的 λmax分别为 2 2 9、2 50、2 2 9、2 65、2 2 5nm,表明吸收光谱严重重叠。在相应的 λmax处 ,其表观摩尔吸光系数分别为 5.61× 1 0 3、7.48× 1 0 3、6.1 5× 1 0 3、7.89× 1 0 3以及 4.35× 1 0 3L· mol-1· cm-1。用偏最小二乘法和迭代目标转换因子法等化学计量学法辅助紫外分光光度法 ,不经分离 ,同时测定了模拟样和小儿苯巴比妥片剂试样中的上述四组分。虽然体系的加和性较差 ,但由于两算法抗交互作用和抗随机误差的能力较强 ,故仍取得了满意的结果。可用于复方药物质量的监控
The λ max of aspirin, phenacetin, caffeine and phenobarbital in the tartaric acid ethanol solution with mass concentration of 0.5 g / L were respectively 2 2 9,2 50,2 2 9,2 65,2 2 5 nm , Indicating a serious overlap of the absorption spectra. At the corresponding λmax, the apparent molar absorptivities were 5.61 × 10 3, 7.48 × 10 3, 6.1 5 × 10 3, 7.89 × 10 3 and 4.35 × 10 3 L · mol -1 cm -1. Partial least square method and iterative target conversion factor method such as chemometrics assisted UV spectrophotometry, without separation, Simultaneous determination of the sample and the analog samples of phenobarbital tablets in the above four components. Although the sum of system is poor, the satisfactory results have been obtained because of the strong anti-interaction and anti-random error of the two algorithms. Can be used for compound drug quality monitoring