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目的:研究脑胶质瘤患者手术前后睾酮水平变化,并分析其临床意义。方法:选取2010年2月到2015年6月我院脑胶质瘤患者80例为研究组,并选择同期颅脑良性肿瘤患者80例为对照组,两组均给予手术治疗,检测术前和术后3天、术后1周患者睾酮水平。结果:研究组术后各病理类型睾酮水平较治疗前显著降低(P<0.05),但不同病理类型之间睾酮水平比较无统计学意义(P>0.05);研究组术前睾酮水平显著高于对照组,比较差异具有统计学意义(P<0.05);术后3天、术后一周研究组睾酮水平与术前比较显著降低,差异具有统计学意义(P<0.05);术后1周研究组睾酮水平与术后3天比较无统计学意义(P>0.05);对照组术前和术后各时间睾酮水平比较无统计学意义(P>0.05)。结论:脑胶质瘤患者会出现睾酮水平紊乱,当睾酮水平明显增高时应警惕脑胶质瘤的可能性。
Objective: To study the changes of testosterone in patients with glioma before and after operation, and to analyze its clinical significance. Methods: From February 2010 to June 2015, 80 patients with glioma in our hospital were selected as research group and 80 patients with benign tumors of the brain in the same period were selected as control group. Both groups were given surgical treatment, Testosterone levels were measured 3 days after surgery and 1 week after surgery. Results: The levels of testosterone in the study group were significantly lower than those before treatment (P <0.05), but the levels of testosterone in different pathological types were not statistically significant (P> 0.05). The level of testosterone in the study group was significantly higher than that before treatment (P <0.05). The level of testosterone in the study group was significantly lower at 3 days after surgery and one week after surgery compared with that before operation (P <0.05), and after 1 week after operation The level of testosterone was not significantly different from that of the other three days after operation (P> 0.05). There was no significant difference in testosterone levels before and after operation in the control group (P> 0.05). CONCLUSIONS: Patients with gliomas develop a disorder of testosterone levels and should be alert to the possibility of glioma when testosterone levels are significantly elevated.