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1,25-(OH),D是VitD活性最强的代谢产物,主要由于25OHD通过甲状旁腺(PTH)-cAMP在肾近曲管激活1,25-OHD-1α羟化酶合成;另一条途径是降钙素(CT)在肾近端直管合成1,25-(OH)_2D。材料和结果 1984年12月～1985年2月对28名健康母亲及其足月顺产儿第1天(脐血)、第5天检查血Ca、P、总蛋白/PTH、尿cAMP肌酐、肾源性cAMP、CT、25-(OH)D及1,25-(OH)_2 D,将其结果与成人进行对照。 1.25-(OH)D与1,25-(OH)_2D:母血25-(OH)D(16.3±6.2ng/ml)明显高于脐血(7.6±4.6ng/ml)和5天婴儿(9.7±3.4ng/ml)的水平三者间用回归线方法,最终的相关系数(r)呈显著性相关。
1,25- (OH), D is the most active metabolite of VitD, mainly due to 25OHD through the parathyroid (PTH) -cAMP in renal proximal tubule activation 1,25-OHD-1α hydroxylase synthesis; the other Pathway is calcitonin (CT) in the proximal renal synthesis of 1,25- (OH) _2D. MATERIALS AND RESULTS: From December 1984 to February 1985, 28 healthy mothers and their first trimester of term (cord blood) were examined. Blood Ca, P, total protein / PTH, urine cAMP creatinine, kidney Derived cAMP, CT, 25- (OH) D and 1,25- (OH) 2D, and the results were compared with those in adults. 1.25- (OH) D and 1,25- (OH) _2D: maternal blood 25- (OH) D (16.3 ± 6.2 ng / ml) was significantly higher than those of umbilical cord blood (7.6 ± 4.6 ng / 9.7 ± 3.4ng / ml) by regression line method, the final correlation coefficient (r) was significantly correlated.