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目的:观察还原型谷胱甘肽对梗阻性肾病所致肾损伤的保护作用。方法:收集我院2010年1月至2011年12月42例梗阻性肾病所致肾损伤的患者,随机分为还原型谷胱甘肽治疗组(n=24)和对照组(n=18)。治疗组在常规治疗的基础上给予还原型谷胱甘肽1 800 mg静脉滴注,每日1次,共治疗14d;对照组仅给予常规治疗。比较两组治疗前、后血肌酐、尿素氮、SOD及尿液β_2-MG、NAG水平。结果:治疗后还原型谷胱甘肽治疗组[(62.9±20.3)μmol/L,(5.7±1.88)mmol/L,(0.35±0.10)mg/L,(10.59±3.55)U/L]较对照组[(109.1±29.6)μmol/L,(7.2±2.23)mmol/L,(0.80±0.26)mg/L,(25.21±7.56)U/L,P<0.05]下降更明显,血清SOD水平明显高于对照组[(399.09±105.42)u/mL vs(257.96±81.15)U/mL.P<0.01]。结论:还原型谷胱甘肽可以减少梗阻性肾病患者肾脏的氧化应激性损伤,有助于肾小球和肾小管功能的恢复。
Objective: To observe the protective effect of reduced glutathione on renal injury induced by obstructive nephropathy. Methods: Forty-two patients with renal injury caused by obstructive nephropathy were collected from January 2010 to December 2011 in our hospital. Patients were randomly divided into treatment group (n = 24) and control group (n = 18) . On the basis of routine treatment, the treatment group was given intravenous drip of 1 800 mg of reduced glutathione once a day for 14 days. The control group was given routine treatment only. Serum creatinine, blood urea nitrogen, SOD, urine β_2-MG, NAG levels were compared between the two groups before and after treatment. Results: The levels of (62.9 ± 20.3) μmol / L, (5.7 ± 1.88) mmol / L, (0.35 ± 0.10) mg / L and (10.59 ± 3.55) U / L] The levels of SOD in the control group were significantly lower than those in the control group [(109.1 ± 29.6) μmol / L, (7.2 ± 2.23) mmol / L, (0.80 ± 0.26) mg / L and (25.21 ± 7.56) U / (399.09 ± 105.42) u / mL vs (257.96 ± 81.15) U / mL, P <0.01]. CONCLUSION: Reduced glutathione can reduce the oxidative stress injury in the kidney of patients with obstructive nephropathy and contribute to the recovery of glomerular and renal tubular function.